Use the quotient rule to find the derivative of
5ex+38x106x5\displaystyle \frac{{{5}{e}^{{x}}+{3}}}{{-{8}{x}^{{10}}-{6}{x}^{{5}}}}

Use e^x for ex\displaystyle {e}^{{x}}. You do not need to expand out your answer. Be careful with parentheses!